Generic Name: dapagliflozin and metformin HCl
Drug Class: sodium-glucose cotransporter 2 (SGLT2) inhibitor and biguanide
When dapagliflozin plus metformin treatment is required, Xigduo XR is an oral prescription medication used to improve glycemic control in persons with type 2 diabetes mellitus. This is prescribed together with proper diet and exercise. This oral medication is not indicated for type 1 diabetes and diabetic ketoacidosis.
This is available in Xigduo XR 5/1000 mg, 10/500 mg, and 10/1000 mg extended-release tablets.
Xigduo XR Mechanism of Action
This is a combination product of an SGLT2 inhibitor and a biguanide. First, it reduces the reabsorption of filtered glucose from the tubular lumen and lessens the renal threshold of glucose, resulting in an increase in urinary glucose excretion. Second, it improves glycemic control by decreasing the production of hepatic glucose, decreasing the absorption of glucose in the intestines, and improving insulin sensitivity through increasing peripheral glucose uptake and utilization.
How to Take Xigduo XR
It is necessary to read the information leaflet or medication guide provided by a healthcare provider before beginning to use Xigduo XR. You must not take any medication unless you have read and comprehended the instructions and uses. For more medical advice or information, consult your doctor or pharmacist.
The only way to take this tablet is by mouth. This is usually prescribed once a day, preferably in the morning. You must take it with a meal. Swallow the extended-release tablet entirely and drink plenty of fluids. Cutting or crushing this product is not recommended because doing so can release all the active ingredients at once, thereby increasing the risk of adverse reactions.
Make a dosing schedule when taking Xigduo XR. Do not increase or decrease your Xigduo XR dosage. You should not take this oral medication more frequently than recommended.
This diabetes medication is only an adjunct to proper diet and regular exercise. It may not work as well if lifestyle changes are not applied. Always eat a healthy balanced meal and do exercise regularly.
Xigduo XR Side Effects
Mild & Common Side Effects:
Severe Side Effects:
-Changes in urine output
-Swelling of the lower extremities
-Yeast infection in the vagina or penis
-High blood sugar
-Low blood sugar
Please keep in mind that this is not an exhaustive list of Xigduo XR’s negative effects.
If you get severe or persistent side effects, stop taking the drug and contact your doctor or another health care expert.
Warnings and Precautions
Do not take Xigduo XR if you have a known allergy to dapagliflozin, metformin, or any inactive ingredients the capsule may contain. Any indicators of major allergic reactions, such as problems breathing, swelling of the face and neck, severe dizziness, swollen lymph nodes, hives/itchiness, and skin rashes, should always be kept in mind. Stop using this oral medication and seek emergency medical treatment right away if this happens.
Xigduo XR may be contraindicated for people with a history of severe asthma, COPD, liver disease, kidney disease, yeast infections, dehydration, vitamin B12 deficiency, anemia, and alcohol abuse. You should also discuss all of your prescription and nonprescription medications, vitamins, and herbal products with your doctor owing to the possibility of drug interactions.
When blood sugar levels are excessively high or too low, symptoms such as dizziness, drowsiness, and blurred vision are typical. When performing duties that need attention and good vision, exercise caution.
Restrict your intake of alcoholic beverages. Alcohol can trigger certain adverse effects. Low blood sugar and lactic acidosis are potentially possible side effects. You must not take diuretics and avoid getting dehydrated as these can also lead to lactic acidosis.
Metformin can cause menstrual changes and promote ovulation. Thus, increasing the chance of getting pregnant. Talk to your healthcare provider about reliable and safe birth control methods, if necessary.
This oral medication should only be taken by pregnant or lactating mothers if absolutely necessary. All potential dangers should be discussed with a healthcare provider. Furthermore, pregnancy can either induce or exacerbate diabetes. Changes in the treatment plan should be discussed with your doctor.
Frequently Asked Questions (FAQs)
How does Xigduo XR work?
This oral diabetes drug works by getting rid of excess glucose through the urine. It also lowers the glucose produced by the liver while increasing insulin sensitivity.
Does Xigduo cause weight loss?
Some people report modest weight loss while taking Xigduo XR However, there is no direct link between Xigduo XR & weight loss.
What is the best time to take Xigduo XR?
It is advised to take this supplement first thing in the morning. You must take it with food to avoid stomach discomfort.
Can you take Xigduo XR twice a day?
Xigduo XR is usually only prescribed once a day. Your dosage will depend on your response to medication, your overall health condition, and the other medications you are taking.
What is the same medicine as Xigduo XR?
Currently, there are no alternatives or generic equivalents to Xigduo XR. If this oral prescription is not working for you, consult your doctor.
Is Xigduo XR over the counter?
You cannot purchase this oral inhalation over the counter. This product is only available with a prescription.
How much does Xigduo XR cost?
You may see the list of prices on this page by clicking here. When you order from Pharma Passport, you’ll get the best prices.