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Are you Looking to Buy Aklief Cream (Trifarotene) from Pharmapassport.

We don't sell this generic-version medication.

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Price Match See Alternative Pricing below for savings

Buy Brand Aklief Cream

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Formulation : Cream
Drug Name Dosage Quantity Price Buy Now
Aklief Cream 0.005% 75 grams $222.21 Add To Cart
Aklief Cream 0.005% 150 grams $424.21 Add To Cart
Aklief Cream
Dosage: 0.005%
Quantity: 75 grams
Price: $222.21
Aklief Cream
Dosage: 0.005%
Quantity: 150 grams
Price: $424.21


Generic Name: trifarotene

Drug Class: retinoid

Aklief Cream Indications

Aklief is a topical prescription cream used for the treatment of acne vulgaris among patients nine years of age and above. Acne vulgaris is a very common condition of the skin that involves blockage of the hair follicles and sebaceous glands. This topical drug lessens the number and severity of acne and makes them heal faster.

Aklief Cream Dosage Forms

This cream is available in Aklief 0.005% topical cream.

Aklief Cream Mechanism of Action

The exact mechanism of this prescription cream is not fully known yet. However, it is thought to act mainly as a retinoic acid receptor or RAR agonist. It modulates target genes that are linked with several processes, such as cell differentiation and mediation of inflammation. This is also known to have depigmentation and skin hydration effects.

How to Use Aklief Cream

Before you start using this topical drug, it is important to read the information leaflet or drug guide given by a health care professional. You must not take or use any medication unless you have understood all indications and directions. Ask your doctor/pharmacist for further medical advice.

This cream must only be administered externally on the skin. This is usually prescribed once a day, in the evening, or as directed by your physician. Make a dosing schedule. It is best to administer this drug at equal intervals. Do not increase or decrease your doses, and do not use it more frequently than advised. Using it in large amounts will not improve your condition but may increase the adverse reactions. Keep using this product until the doctor prescribes it.

Aklief Cream Directions

  1. Thoroughly wash your hands before applying this topical cream.
  2. Cleanse the affected area of the skin using a mild cleanser and pat it dry.
  3. Dispense a small amount of cream onto your fingers.
  4. Using your fingers, put a thin layer of the cream to the affected area and spread it evenly. Allow it to be absorbed prior to applying other products, especially on your face. Avoid getting the cream into your mouth and eye area.
  5. Once you are done, wash and dry your hands again.

Aklief Cream Side Effects

Mild & Common Side Effects:

    • Mild stinging or burning
    • Skin redness
    • Dryness
    • Scaling
    • Itching

Serious Side Effects:

    • Skin inflammation
    • Skin blisters
    • Skin thinning
    • Skin discoloration
    • Eye redness
    • Eye watering
    • Eyelid swelling

Note that the above is not a complete or a full list of Aklief side effects.

If you experience severe or persistent adverse reactions, discontinue medication and talk to your doctor or health care professional.

Warnings and Precautions

Do not administer this prescription drug if you have a known allergy to trifarotene, tretinoin, any vitamin A-related drugs, or any Aklief Cream ingredients it may contain. Always watch for any signs of serious allergic reactions, such as trouble breathing, swelling of the face and neck, severe dizziness, lymph nodes swelling, hives/itchiness, and skin rashes. If any of these happen, stop taking this oral medication and seek emergency medical help immediately.

This topical medication may be contraindicated for people with a history of eczema or any skin infection. Additionally, because of possible drug interactions, you should discuss all the prescription medications, OTC medications, supplements, and herbal products you are taking.

Trifarotene cream will make your skin more sensitive to the sun. It will be best to limit your time under direct sunlight and avoid indoor tanning, including the use of sunlamps and tanning booths. Remember to wear sunscreen when going out and always wear protective clothing.

Do not wax, do electrolysis, and use chemical depilatories for hair removal on areas where you use this medication. Certain procedures or chemicals can increase skin irritation or inflammation.

Use this cream with utmost caution if you have recently used products that contain salicylic acid, sulfur, and resorcinol. You must wait until the effects of these products on the skin have subsided before applying Trifarotene cream.

Pregnant moms should use this topical medication only if extremely necessary, as it is not yet known if it can possibly cause harm to unborn babies. For breastfeeding moms, it is also unknown if it can pass into the breastmilk or if it can affect nursing infants. You must discuss all the possible risks with your doctor before deciding to use this product.

How much does Aklief Cream cost in Canada?

Get the best deals when you order your prescription drugs from PharmaPassport. We provide the lowest prices of medication for our patients.

You may check the Aklief Cream price in Canada on this page.

Frequently Asked Questions (FAQs)

What is Aklief used for?

Trifarotene cream is being used to lessen the severity and numbers of acne, especially facial and truncal acne. You can also use Aklief Cream for acne scars as it promotes depigmentation. It can be used by children 9 years old and up.

Can I use Aklief Cream for dark spots?

This topical medication may not work with dark spots unless the spots or scars are caused by acne. It can also help prevent acne scars from forming. 

Is Aklief good for wrinkles?

No, you should not use Aklief Cream for wrinkles. This medication may not be effective for other skin conditions aside from acne vulgaris. Talk to your dermatologist about the products that can help you with your concerns.

How long before you see Aklief results?

You are expected to see results after two weeks of using this medication every day. However, clearing your acne may take a few weeks to a few months.

Does Aklief dry out the skin?

Yes. Among the common side effects of applying this cream are skin dryness and scaling. To avoid this, apply moisturizer to the affected area once the cream has already been absorbed.

Where can I buy Aklief Cream?

Aklief Cream – Buy online from Note that this product is available only by prescription. You must present a valid prescription from your physician when you purchase this topical cream.

Additional information

Scientific Name:






Quantities Available:

75 grams, 150 grams

The contents on this page was provided by third parties to The information for Aklief Cream (Trifarotene) is not intended to substitute for qualified health care professional's advice. Please consult with your doctor if you have any questions or require medical advice.

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