Emend is an oral prescription drug used to prevent acute and delayed nausea and vomiting due to initial and repeat courses of HEC or highly emetogenic cancer chemotherapy, especially high-dose cisplatin. It also prevents nausea and vomiting caused by initial and repeats courses of MEC or moderately emetogenic cancer chemotherapy.
This is available in Emend 80 mg and 125 mg capsules.
Emend Mechanism of Action
It inhibits emesis caused by cytotoxic chemotherapeutic agents, like cisplatin, through central actions. It is known to cross the blood-brain barrier and occupies brainNK1 receptors, but it has little to no affinity for corticosteroid, serotonin, and dopamine receptors.
How to Take Emend
Before starting to take this medication, it is necessary to read the information leaflet or medication guide given by a healthcare professional. You must not take Emend unless you have understood the uses and directions. For further medical advice, speak with your doctor.
This tablet is only meant to be taken by mouth. Take it about an hour before the start of your chemotherapy session. Then, only once daily for the next two days, preferably in the morning. It is suitable for consumption with or without meals. Swallow the capsule entirely and drink fluids right after.
It is best to plan a dosing schedule so you don’t forget to take your medication. Do not increase or decrease your Emend dose. This oral drug should be taken exactly as directed.
Emend Side Effects
Mild & Common Side Effects:
Severe Side Effects:
-Severe abdominal pain
-Inability to urinate
Note that this is not a full/complete list of the side effects of Emend.
If you experience severe or persistent adverse reactions, discontinue medication and talk to your doctor or any health care professional.
Warnings and Precautions
Do not take this prescription drug if you have a known allergy to aprepitant, fosaprepitant, or any inactive ingredients the capsule may contain. Always watch for any signs of serious allergic reactions, including trouble breathing, swelling of the face and neck, severe dizziness, swollen lymph nodes, hives/itchiness, and skin rashes. Stop taking this oral medication and seek emergency medical help immediately if any of those occurs.
This medication may be contraindicated for people with a history of liver disease or kidney disease. Discuss all prescription medications, nonprescription medications, supplements, and herbal products you are taking with your doctor.
Pregnant and breastfeeding moms must take this oral drug only if extremely necessary. It is necessary to discuss all the possible risks with a healthcare provider.
Frequently Asked Questions (FAQs)
What is Emend used for?
Physicians prescribe Emend for nausea and vomiting caused by cancer chemotherapy. This is usually administered 1 hour before starting the chemotherapy session.
Can you take Emend daily?
This oral drug is not meant for long-term use. Doctors only prescribe one to three doses of this medication at a time.
Does Emend cause QT prolongation?
There is no direct link between aprepitant and QT prolongation. However, this oral medication can cause increased plasma concentration of pimozide, which can cause QT prolongation.
What is the difference between Emend and Zofran?
Emend vs Zofran – These medications are used to prevent nausea and vomiting induced by cancer chemotherapy. The difference lies in their forms. Zofran is also available in orally disintegrating tablets.
Is Emend available in Canada?
This product is approved and is available in Canada for chemotherapy-induced nausea and vomiting. You may buy this drug from our online pharmacy.
Is there a generic for Emend?
Unfortunately, generic aprepitant is not available from Canada. Do not replace this medication without consulting your doctor.
What is the cost of Emend?
You may see the list of prices on this page here. Get the best deals when you order your prescription drugs from Pharma Passport.