Generic Name: sirolimus
Drug Class: mammalian target of rapamycin (mTOR) inhibitor
Rapamune is an oral prescription drug used as a prophylaxis for organ rejection among patients 13 years of age and above. This is mostly given to patients who had a kidney transplant. This is also used to treat patients with lymphangioleiomyomatosis.
Rapamune Dosage Forms
This is available in Rapamune 1 mg, and 2 mg tablets.
Rapamune Mechanism of Action
This immunosuppressant inhibits the activation and proliferation of T-lymphocyte, which is a response to the antigenic and cytokine stimulation through a process that differs from other immunosuppressants. At the same time, it also inhibits the production of antibodies. Suppressing the body’s defense system helps the body accept the new organ after a kidney transplant.
How to Take Rapamune
Before you start taking Rapamune, it is necessary to read the information leaflet or medication guide given by a healthcare professional. Ensure that you understand the directions and use of any medication before taking it. Consult your doctor or pharmacist for additional information or advice.
Rapamune tablet is usually prescribed once a day and is meant to be taken by mouth. You may take this oral medication with or without a meal. If you feel stomach upset, take it with food. Swallow the oral tablet entirely and drink fluids right after. Cutting, crushing, or chewing this medication is not recommended.
Make a dosing schedule to avoid missing your doses. Do not increase or decrease your Rapamune dosage. You should also not take this oral drug more frequently than advised.
Rapamune Side Effects
Mild & Common Side Effects:
Severe Side Effects:
-Persistent nausea and vomiting
-Easy bruising or bleeding
-Changes in urine output
-Mental or mood changes
Note that this is not a full/complete list of the side effects of Rapamune.
If adverse reactions are severe or persistent, stop taking the drug and call your doctor immediately.
Warnings and Precautions when using Rapamune
Do not take this prescription drug if you have a known allergy to sirolimus, temsirolimus, or any inactive ingredients the tablet may contain. Watch for hives/itchiness, swollen lymph nodes, trouble breathing, swelling of the face or neck, severe dizziness, and skin rashes that might indicate an allergic reaction. In such cases, you should stop taking this medicine and seek emergency medical attention.
This medication may be contraindicated for people with a history of certain medical conditions like any recent infections, high cholesterol and triglyceride levels, cancer, and liver disease. Moreover, you should discuss all prescription, nonprescription, and herbal products you are taking due to drug interactions.
A weakened defense system can be caused by the use of this mTOR inhibitor. This drug can possibly worsen an infection or make you more likely to get an infection. Avoid people who are experiencing or have recently experienced flu, chickenpox, or measles.
This antibiotic can make you more sensitive to sun exposure. It is necessary to minimize or avoid exposure to the sun. You should also avoid indoor tanning. Wear protective clothing and apply sunblock lotion or cream when going out.
Sirolimus and grapefruit may interact and cause adverse reactions. This is because grapefruit contains compounds that can negatively affect statins. Do not eat grapefruit and drink grapefruit juice while you are on this therapy.
It is best for pregnant and breastfeeding moms to avoid taking this oral medication. It is known to cause undesirable effects on unborn children, and it can also pass into breastmilk.
How much does Rapamune cost in Canada?
This drug is a very expensive drug but is reasonable for its effectiveness. We also offer generic for a much lower price.
Frequently Asked Questions (FAQs)
What is Rapamune used for?
Rapamune is an oral drug used to avoid organ rejection among those who underwent a kidney transplant. It is also used for lymphangioleiomyomatosis.
Can Rapamune affect fertility?
This type of medication may affect fertility for both men and women. Women are also advised not to get pregnant while on this medication as it can cause undesirable effects.
Does Rapamune cause weight loss?
This type of oral drug is not directly linked to weight loss. If you experience sudden weight changes when using this medication, you must notify your physician.
How long should I use Rapamune?
You must talk to your healthcare provider regarding the length of therapy. It is important not to alter your Rapamune level or take it more frequently than prescribed.
Is Rapamune an immunosuppressant?
Yes, this medication weakens one’s immune system. You should avoid getting to people who have an infection when taking this type of drug.
Do I need a prescription for Rapamune?
This product is a prescription drug. Avoid people who are experiencing or have recently experienced flu, chickenpox, or measles.