Generic Name: fluticasone propionate and salmeterol
Drug Class: corticosteroid and long-acting beta2-adrenergic agonist
Advair Diskus Indications
Advair Diskus (fluticasone propionate-salmeterol) is an oral inhalation indicated as a maintenance treatment for asthma among patients 4 years of age and older. It is also used as maintenance treatment of airflow obstruction and reducing exacerbations among patients with COPD or chronic obstructive pulmonary disease.
This inhalation is not indicated for acute bronchospasm or asthma that can be managed by inhaled corticosteroid and occasional use of short-acting beta2-agonists.
Advair Diskus Dosage
This is available in Advair Diskus 500/50 mcg, 250/50 mcg, and 100/50 mcg oral inhalation powder.
Advair Diskus Mechanism of Action
Fluticasone propionate, a tri fluorinated corticosteroid, has been shown to inhibit multiple cell types and mediator production or secretion that are involved in the asthmatic response. It also exhibits potent anti-inflammatory activity.
Salmeterol xinafoate, a long-acting beta2-adrenergic agonist, works by stimulating the enzyme responsible for the conversion of adenosine triphosphate to cyclic AMP. This causes the relaxation of smooth bronchial muscle and inhibition of the release of mediators involved in immediate hypersensitivity, especially mast cells.
How to Use Advair Diskus
Before you start using Advair Diskus, it is necessary to read the information leaflet or medication guide given by a healthcare professional. You must not use any medication unless you have understood all the information regarding it. Ask your doctor or pharmacist for further medical advice or additional details.
Advair Diskus is only meant to be inhaled orally. This is usually prescribed twice daily, twelve hours apart. Keep a dosing schedule to prevent missing doses. In case of forgetting a dose, administer it right away, except if it is almost time for the next one. Do not increase or decrease your Advair Diskus dosage or alter your frequency as they are based on your overall medical condition, other drugs you are taking, and response to therapy. You must also keep taking this medication and use it exactly as prescribed.
Step by Step Guide on using Advair Diskus:
- Open the inhaler by holding it with one hand and using the other hand to push the thumb grip away until the mouthpiece shows. The grip will snap into place if it is correctly opened.
- In a flat, horizontal-level position, hold the device. The mouthpiece should be facing you. Push the lever away from the mouthpiece until you hear it click. Check the counter, and when it says “1”, it means it is ready for use.
- Exhale deeply and fully. Hold your breath while you put the mouthpiece into your mouth and close your lips around it.
- Inhale quickly but deeply through the mouth.
- Hold your breath for ten seconds or more and remove the Diskus from your mouth.
- Exhale slowly. You may taste or feel the fine powder in your mouth at this point.
- Close the device by placing your thumb on the grip again and sliding it back towards you until you hear the click.
- Rinse your mouth with water. Do not swallow it.
Advair Diskus Side Effects
Mild & Common Side Effects:
Severe Side Effects:
-High blood pressure
-Shortness of breath
-White patches in the mouth
-Mental or mood changes
-Increased thirst or urination
-Infection (fever, chills, persistent sore throat)
Note that this is not a full/complete list of the side effects of Advair Diskus.
If you experience severe or persistent adverse reactions, discontinue using your Advair Diskus inhaler and consult your doctor or any healthcare professional.
Precautions / Warnings
Do not use this respiratory inhalant if you have a known allergy to fluticasone, salmeterol, lactose, milk proteins, or any inactive ingredients the inhalation powder may contain. Always lookout for signs of a severe allergic reaction, including difficulty breathing, swelling of the face and neck, severe dizziness, hives/itchiness, and skin rashes. If this occurs, discontinue using the inhaler and seek emergency medical attention.
Some diseases or disorders may greatly impact how your body will respond to the treatment. Disclose your entire medical history to your doctor, including osteoporosis, hypertension, heart diseases, diabetes, hyperthyroidism, seizures, liver disease, eye problems, and current or past infections. Due to possible drug interactions, it is also necessary to talk about all the prescription drugs, nonprescription drugs, supplements, and herbal products you are taking.
You may experience QT prolongation while on this treatment. This heart rhythm irregularity could be considered a medical emergency if characterized by fainting, severe dizziness, and fast/irregular heartbeat. You can avoid this condition by staying hydrated and avoiding diuretics/water pills. Your physician may also have to monitor your blood potassium and magnesium levels from time to time.
Advair Diskus may possibly mask signs of infection. You are more likely to get infected, or your current infections may get worse while using this medication. Avoid coming in contact with patients who have infections, such as flu and measles.
It is not known if this oral inhalation can cause harm to pregnant moms and unborn babies. For breastfeeding moms, it is also unknown if this drug can pass into breast milk. Thus, you must use this inhaler only if extremely necessary.
Frequently Asked Questions
1. Does Advair Diskus contain steroids?
Yes, this inhalation powder contains steroids.
2. Can I use Advair Diskus for asthma attacks?
This drug is only used as a maintenance treatment for asthma and COPD. Using it as a rescue inhaler is not recommended.
3. Does Advair Diskus affect blood pressure?
This respiratory inhalant may increase your blood pressure.
4.What is Advair Diskus classification?
This inhaler is classified as a corticosteroid and long-acting beta2-adrenergic agonist.
5.How much does Advair Diskus cost?
This product description includes the prices for the different strengths of Advair Diskus. Check out the top of this page.