Generic Name: sacubitril and valsartan
Drug Class: neprilysin inhibitor and angiotensin II receptor blocker (ARB)
Entresto is an oral prescription used to lessen the risk of hospitalization and cardiovascular death among people with chronic heart failure, especially those with left ventricular ejection fraction below normal. It is also prescribed for pediatric patients diagnosed with symptomatic heart failure and systemic left ventricular systolic dysfunction.
Entresto Dosage Forms
This is available in Entresto 24/26 mg, 49/51 mg, and 97/103 mg film-coated tablets.
Entresto Mechanism of Action
The action of this drug for patients with heart failure is centered on increasing the levels of peptides, especially natriuretic peptides. It also inhibits angiotensin II effects by selectively blocking angiotensin I receptors.
How to Take Entresto
Before starting to take this medication, it is necessary to read the information leaflet or medication guide given by a healthcare professional. You must not take any medication unless you have understood the uses and directions. For more medical advice or additional details, consult your doctor or pharmacist.
This tablet is only intended to be taken orally. This is usually prescribed twice a day, with or without a meal. Take the tablet and drink fluids immediately afterward. Your doctor may start with a low Entresto dose and gradually increase it to avoid severe adverse effects. Additionally, remember not to take ACE inhibitors like captopril and enalapril within 36 hours after taking this medication, as this can also trigger side effects.
Make a dosing schedule. Do not increase or decrease your dose. You should not also take this oral drug more frequently than advised.
Entresto Side Effects
Mild & Common Side Effects:
Severe Side Effects:
-Signs of kidney problems
-High level of potassium in the blood
Note that this is not a full/complete list of the side effects of Entresto.
If you experience severe or persistent adverse reactions, discontinue medication and call your doctor or healthcare professional.
Warnings and Precautions
Do not take this prescription drug if you have a known allergy to sacubitril, valsartan, other ARBs, ACE inhibitors, and any inactive ingredients the tablet may contain. Always be watchful for any signs of serious allergic reactions, including trouble breathing, swelling of the face and neck, severe dizziness, swollen lymph nodes, hives/itchiness, and skin rashes. Stop taking this oral medication and seek emergency medical help immediately if this occurs.
This medication may be contraindicated for people with a history of dehydration, hyperkalemia, kidney problems, liver problems, and angioedema. Also, due to possible drug interactions, you should discuss all the prescription medications, nonprescription medications, supplements, and herbal products you are taking.
Dizziness is a common adverse effect of this medication. Practice safety caution when doing tasks that would need alertness, especially driving. You must also limit your consumption of alcoholic drinks.
Pregnant moms must avoid this medication because it is known to cause harm to unborn babies. For breastfeeding moms, it is unknown if it can pass into breast milk. Talk to your healthcare provider about all the possible risks.
Frequently Asked Questions (FAQs)
1. What is Entresto used for?
Physicians prescribe Entresto for heart failure. It enhances the left ventricular ejection fraction, which helps supply more blood and oxygen throughout the body.
2. Is Entresto used for high blood pressure?
This oral medication can lower blood pressure and can cause symptomatic hypotension. This is used off-label to treat hypertension.
3. What is Entresto drug class?
This drug is classified as an angiotensin receptor- neprilysin inhibitor and angiotensin II receptor blocker. You may read its mechanism of action above.
4. Does Entresto make you lose weight?
There is no known link between Entresto and weight gain or weight loss. However, heart failure itself can cause rapid weight changes.
5. What is the best time to take Entresto?
This tablet is usually taken twice daily and should be taken at the same time each day. You may take it upon waking up and before going to bed.
6. How much does Entresto cost?
You may see the list of Entresto prices on this page. To get the best deals, you may order from our online pharmacy.
7. Is there a cheaper version of Entresto?
Currently, this medication for heart failure has no generic equivalents. This is why there are no cheaper alternatives to this drug.
8. Do you need a prescription for Entresto?
This product is a brand-name prescription drug. You must secure a valid prescription before purchasing this medication from any pharmacy.